The relationship between ILC2-associated molecules and auto-antibodies in Hashimoto's thyroiditis
ZHANG Danyi
PENG Jingjing
QI Chen
SU Zhaoliang
WANG Shengjun
XU Huaxi
Abstract：Group Ⅱ innate lymphoid cells (ILC2) is a newly discovered non B non T lymphocyte,which is capable of producing large amounts of IL-13 and IL-5 when stimulated by IL-25 and IL-33,and participate in the maintenance of Th2 cell polarization.Hashimoto's thyroiditis is a kind of organ specific autoimmune disease accompanied by increased levels of autoantibodies such as ATG and ATPO in serum of patients.The relationship between ILC2 and autoantibodies has not been reported in Hashimoto's thyroiditis.In this study,we detected the expression levels of ILC2-associated cytokines and transcription factor in peripheral blood from patients with Hashimoto's thyroiditis,and analyzed the correlation between the expression levels of ILC2-associated cytokines and autoantibodies.The results showed that the expression levels of ILC2-associated cytokines and transcription factor were significantly increased in Hashimoto's thyroiditis,and the increased level of ILC2-associated molecules were positively or modestly correlated with ATG or ATPO autoantibody.All result prompted that the activity of ILC2 is closely related to autoantibodies production in patients with Hashimoto thyroiditis,which may be performed by maintaining the Th2 polarization or inhibiting IL-10 secretion.
Keywords：Hashimoto's thyroiditisGroup Ⅱ innate lymphoid cellsAutoantibodiesTranscription factorCytokine
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 338-342 )