The clinical value of anti-SSA, anti-SSB, anti-Ro52 antibodies in autoimmune diseases
ZHOU Yi
WANG Yanping
Abstract：This study performed to investigate the clinical significance of anti-SSA,anti-SSB and anti-Ro52 antibodies in the diagnosis of autoimmune diseases (AID),and to investigate whether the results of related laboratory test in SLE,SS,RA were different between the single positive group and the multiple positive group of anti-SSA/ SSB/Ro52 antibodies.Total of 1 007 patients with positive results of SSA / SSB / Ro52 antibody were selected and their laboratory test results and clinical final diagnosis were analyzed.Data showed that there was a significant difference in the proportions of AID and non-AID diagnosis among the different combinations of anti-SSA/SSB/ Ro52 antibodies,and the percentage of AID increased with the increase of positive antibody.Moreover,the increase of IgG in SLE patients,the reduction of lymphocytes in RA patients,the decrease of C3 and the elevation of globulin IgG in SS patients were significantly different between the single positive group and the multiple positive group.In conclusion,anti-SSA,anti-SSB,anti-Ro52 antibodies can be used as the screening indexes of AID;the more positive antibody is,the more likely the diagnosis of AID is,suggesting that multiple positive antibodies may be related to the activity or severity of diseases.
Keywords：Anti-SSA antibodyAnti-SSB antibodyAnti-Ro52 antibodyAutoimmune diseaseClinical value
Publication Date：2017-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 327-331 )