Th17 cells and colorectal cancer
ZHOU Qian
JIN Tao
LIAN Xiaoyuan
ZHANG Zhizhen
Abstract：Under normal condition,T helper 17 (Th17) cells play an important role in keeping intestinal immune homeostasis and resisting to external pathogenic microorganisms invasion.However,recent studies show that Th17 cells' abnormal differentiation and activation and their secreted cytokines (IL-17,IL-22,IL-21,IL-26) have an important role in the development of colorectal cancer.This article focuses on reviewing the role of Th17 cells and their secreted cytokines in the development and advance of colorectal cancer,and summarizes their potential mechanism,which will bring some new ideas for the prevention and treatment of colorectal cancer.
Keywords：Th17 cellCytokinesColorectal cancer
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)