The clinical signifance of B7-H3 expression in the monocytes of rheumatoid arthritis
SUN Jing
GAO Li
WU Pingping
ZHANG Yaqin
GUO Yundi
LIU Cuiping
Abstract：To analyze B7-H3 expression on monocytes in rheumatoid arthritis (RA) and it's correlation with clinical disease parameters or the level of inflammatory cytokine,peripheral blood of 69 cases of RA patients and 38 cases of healthy controls were collected.Peripheral blood mononuclear cells (PBMC) were isolated and the CD14 and B7-H3 expressions were analyzed by flow cytometry;ELISA was carried out for IL-6 and TNF-α expression,and the correlation between B7-H3 expression and disease parameters or inflammatory cytokine was evaluated.Data showed that B7-H3 was significantly up-regulated on monocytes in RA patients than that in healthy controls,and has correlation with the disease stage,the length of the disease course,the DAS28 score,the tender joint count,the swollen joint count and the TNF-α,IL-6 secretion.These findings will help to clarify the function of B7-H3,including its potential role as a biomarker for RA.
Keywords：Rheumatoid arthritisB7-H3TNF-αMonocytes
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)