Modulation of dendritic cells and CD4+ T cells in mouse lungs during Streptococcus pneumonia
Abstract：To investigate the alteration of dendritic cells (DCs) and CD4+T cells after Streptococcus pneumoniae (S.pneumonia) infection,6-8 weeks Balb/c mice were divided into Streptococcus pneumonia infection and mock infection groups.The levels of CD103+DC,CD11b+DC,pDC and the subsets of CD4+T cells in lungs were detected by flow cytometry on 2nd and 5th day after infection.2 and 5 days after infection,CD103+DC and pDC levels in S.pneumonia infection groups were significantly elevated (P＜0.01),but the level of CD11b + DC was significantly decreased (P＜0.05) as compared with mock infection groups.IL-17A+CD4+T cells and Foxp3+Tregs levels in S.pneumonia-infected group were increased compared with mock-infected group on 2nd and 5th day after infection (P＜0.05);IL-4+CD4+T cells level was similar between mock and S.pneumonia infection group,while IFN-γ+CD4+T cells were significantly increased 5 days post S.pneumonia infection when compared with mock-infected group (P＜0.01).Taken together,S.pneumonia infection can induce CD103+DC,pDCs production,promotes IL-17A+CD4+T cells and Tregs differentiation.
Keywords：Streptococcus pneumoniaInfectionDendritic cellsCD4+T cells
Publication Date：2016-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)