Progress in complement cleavage product C5a
Abstract：The 74 amino acids glycoprotein, complement component 5a (C5a), is a potent pro-inflammatory mediator cleaved enzyma tically from its precursor, C5, upon activation of the complement cascade. C5a is quickly metabolized by carboxypeptidases, forming the less potent C5adesArg. Acting via a classical G protein-coupled receptor pathway, C5a could combine with C5aR and plays an important role both in natural immunity and adaptive immunity. While C5a's actions at the more recently discovered non-G protein-coupled receptor remain unclear. The study shows that CSa is the important pathogen, so making CSa inhibition an attractive therapeutic strategy.
Keywords：ComplementC5aC5aRActivation
Publication Date：2010-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 362-365 )