Relationship between FOXP3 gene polymorphism and alopecia areata

Abstract：To investigate whether the FOXP3 gene polymorphisms was associated with the occurrence or severity of alopecia areata (AA), we recruited 240 AA patients and 248 normal controls to study. SNPs (rs3761547, rs3761548) were defined for FOXP3 gene by using the data of Han population from the Hapmap homepage. PCR-RFLP was used for the genotyping and statistics were employed for analyzing SNP. A significant difference of the three genotypes at rs3761548 site was observed between patients and controls (P= 0.015). But no association was found at rs3761547 between A A and control group (P = 0.12). Logistic aggression model analysis indicated that allele A of rs3761548 was associated with A A. Estimated haplotype frequency distribution of rs3761547 and rs3761548 showed significant difference of the haplotype GA and GC between cases and controls. Logistic aggression model analysis indicated that haplotype GA is the danger factor (OR: 3.2010; 95% CI: 2.1538-4.7573), but haplotype GC was the protection factor (OR: 0.4831; 95% CI: 0.3577-0.6526). The results show that the rs3761548 genetic polymorphisms of FOXP3 gene may be associated with AA, which may be a risk factor of AA in Chinese Chongqing Han population. But there was no association between the rs3761547 and A A.