Predicting B cell epitopes of ECSM2 extracellular domain with bioinformatics
GOU Lantu
YANG Jinliang
Abstract：To predict B cell epitopes of endothelial cell-specific molecule-2 (ECSM2)extraceUulax domain.Basing 0n the amino acids of ECSM2 extracellular domain,the sequence specificity,secondary structure,and various parameter including polarity,hydrophilici-ty,flexibility and surface accessibility were analyzed with public bioinformatics tools.And then,professional tool was applied to Dredict po-tential B cell epitopes of ECSM2 extraceUular domain.Finally,the data obtained from bioinformatics were comprehensiveIv analyzed t0 pre-diet the possible epitopes.The analysis showed the region encoding amino acid residues 69-93 of ECSM2 was probably the dominant epi-tope,because this short peptide region contains four overlapping potential epitopes.The epitopes concluded by bioinformatics provide theo-retical references for isolating specific antibodies targeting vascular endothelial cell from antibody library or hybridoma cell library.
Keywords：ECSM2B cell epitopeBioinformatics
Publication Date：2010-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 156-160 )