Activity of c-fas inducing factor and autoantibodies in serum of patient with schizophrenia

LIU Hui; SHAO Yanhua; WANG Jiaxue

Abstract：The aim of this paper is to explore co-relation between c-fas inducing factor and autoantibodies in schizophrenia. The first-episode patients with schizophrenia were designated to first-episode group; the symptomatic relief patients with schizophrenia were designated to medicinal treatment group; the health people were designated to control group. The serum from each group were analyzed to detect antinuclear antibody (ANA), anticardiolipin antibody (ACA) and rheumatoid factor (RF), and also cultured with lymphoeyte of health individual to detect activity of c-fas inducing factor. The levels of ANA and ACA in first-episode were significantly higher compared with control group (P<0.01); there was no difference between the two groups about RF (P > 0.05). The levels of ANA, RF and ACA in medicated patients were no significantly difference compared with control (P > 0.05 ). The activity of c-fas inducing factor in first-episode group was increased compared with control and significant difference was found (P < 0.01 ), but there was no difference of c-fas inducing factor bet ween the medicinal treatment and control group. There were correlation between the autoantibodies (both ANA and ACA) and activity of c-fas inducing factor, c-fas inducing factor in serum from schizophrenia may be play an important role in the autoantibodies rising.