Advances in investigation of IL-27 and its immunological functions
LIU Lihua
SHAN Baoen
Abstract：Interleukin (IL)-27 is a new member of the IL-6/IL-12 family, composed of p28 and EBV-indured gene 3 (EBI3) subunita.Initial studies on the biology of IL-27 provided evidence of a role for this cytokine in the initiation of Th1 responses; however, subsequent work using models of pathogen-induced and autoimmune infammation have indicated that IL-27 has broad inhibitory effects on Th1, Th2 and Th17 subsets of T cells as well as the inducible regulatory T cells.This review summarizes the immunological characteristic of IL-27 and its functions in inflammation or tumor immunity, also it will give a novel application of IL-27.
Keywords：Interleukin-27Immune responseT cell subsets
Publication Date：2010-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：6( 81-86 )