Expression and function of miRNAs in hematopoietic lineages
YAN Hongbin
JIA Wanzhong
GAO Shandian
CAI Xuepeng
Abstract：MicroRNAs (miRNAs) are approximate 19-24 nucleotide long non-coding RNAs that post-transcriptionally modulate gene expression.They are found in almost all species: virus, plant, nematode, fly, fish, mouse, human, and are implicated in a wide array of cellular and developmental processes.Microarray-based miRNA profiling is being brought to the discovery of miRNAs specific to different hematopoietic lineages.Furthermore, the functional assays performed in tissue cultures to discover miRNAs involved in immune responses in combination with the reports of miRNA-transgenic or miRNA-knockout mouse models have helped elucidate the miRNA roles in the de-velopment and function of immune system.Abnormal patterns of hematopoietic-specific miRNAs have been found in different types of can-cers and miRNA-based gene therapy is being considered as a potential technology for controlling immunological disorders and cancers.The purpose of this review is to discuss recent findings related with the expression and function of miRNAs in hematopoietic lineages.
Keywords：MicroRNA(miRNA)Hematopoietic lineageImmune responseCancerCytokinesTNF-α
Publication Date：2010-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 74-80 )