Changes of serum levels of IL-4 and IL-10 in patients with nephrotic syndrome and its clinical significance
FAN Xingzhong
LI Hong
LIU Wenfeng
ZHAO Jianqiang
Abstract：To investigate the roles of interleukin-4(IL-4)and interleukin-10(IL-10)in pathogenesis of nephrotic syndrome(NS) and its clinical significance.Serum levels of IL-4 and IL-10 in 52 patients with NS were determined by ELISA at pre-treatment and 4 weeks after treatment with prednisone and cyclophosphamide.Serum level of IL-4 in NS patients was significant higher than those in healthy controls (P <0.01),and there was a positive correlation between serum IL-4 level and serum β_2-MG(n=52,r=0.352,P<0.05),while no significant difference of serum IL-10 levels was found between NS group and healthy controls.At 4 weeks after treated with prednisone and cyclophos-phamide.the serum levels of IL-4 and IL-10 as well as the 24-hour urinary protein excretion were significant lower than those in pre-treated NS patients(P<0.05).The results imply that IL-4 and IL-10 may take part in immune pathogenesis of NS,while prednisone and cyclophosphamide may have a significant inhibiting effect on the production of IL-4 and IL-10 in NS.thus the immunotherapy of NS may be adjusted according to the immune activity of disease (fincluding anti-inflammatory immune-regulating cytokines IL-4 and IL-10).
Keywords：Nephrotic syndromePrednisoneCyelophosphamideIL-4IL-10
Publication Date：2010-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 56-57,62 )