Relevance of the expression of TRAIL and its receptors in the villi to unexplained recurrent spontaneous abortion
BAI Huiling
LI Xiuming
ZHAO Yueping
XU Zhixi
MA Yuanfang
Abstract：TNF-related apoptosis inducing ligand(TRAIL) and its receptors have high homology with Fas/FasL, which play an impor-tant role in maternal immune tolerance to fetus.In this study, we evaluated the expressions of TNF-related apoptosis inducing ligand (TRAIL) and its receptors in the placental villi of the patients and its relevance to unexplained recurrent spontaneous abortion (URSA).Fif-teen patients of URSA who are of 45-60 d of pregnancy were set as the study group and 15 healthy women of induced abortion as the control group.The expressions of TRAIL and its receptors in placental villi of the two groups were measured with immunohistochemistry; and then the differences of the protein expressions of TRAIL and its receptors in the placental villi of the two groups were compared by variance anal-ysis and test.The protein expressions of TRAIL and its receptors DR4 and DR5 were upregulated, but the protein expressions of the recep-tors DcRl and DcR2 were downregulated (P < 0.05) in the placental villi of the study group compared with the control group.The results indicate that TRAIL and its receptors may be one of the mechanisms leading to spontaneous abortion.
Keywords：TRAILDR4DR5Unexplained recurrent spontaneous abortionVillus
Publication Date：2010-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 53-55 )