Haematopoietic negative regulatory factors in patients with paroxysmal nocturnal hemoglobinuria and aplastic anemia
WANG Shuye
WANG Wei
CAO Fenglin
YANG Xijing
Abstract：Objective To detect the expression levels of IFN-γ, TNF-α, and TGF-β1 in peripheral blood plasma of patients with paroxysmal nocturnal hemoglobinuria (PNH) and aplastic anemia (AA) for studying the relationship of the expression levels of IFN-γ, TNF-α, TGF-β1 with the pathogenesis of PNH and AA. Methods Peripheral blood was collected from 18 patients with PNH,20 patients with AA and 15 controls. Enzyme-linked immunosorbent assay (ELISA) was used to measure the expression levels of IFN-γ, TNF-α, and TGF-β1in plasma. Results The IFN-γ and TNF-α levels in AA patients were higher than those in controls (P <0.05 ) ; the TGF-β1level in AA patients was much higher than that in controls (P<0.01). The IFN-γ, TNF-α, and TGF-β1 levels in PNH patients were much higher than those in controls (P<0.01). The TNF-ot level in PNH group was higher than that in AA group (P <0.05 ), while the IFN-γand TGF-β1 levels in PNH group were much higher than those in AA group (P<0.01). Conclusion The results suggest that the haematopoietic negative regulatory factors, such as IFN-γ, TNF-α and TGF-β1 , could inhibit hematopoietic cells in PNH and AA patients, which imply that the parasecretion of cytokines may contribute to the pathogenesis of PNH and AA.
Keywords：paroxysmal nocturnal hemoglobinuriaaplastic anemiahacmatopoietic negative regulatory factors
Publication Date：2009-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 431-432,445 )