Dynamic regulating of the reactivity of key molecules SYK and BTK controls the B cell receptor signaling pathway
LIU Shunhui
XIAO Lanfeng
Huang Shulin
Abstract：Objective To develop and simulate a dynamic model dealing with the quantitatively regulatory relationship among interacting molecules involved in B cell receptor signaling pathway. Methods Based on KEGG database and related literatures in Eng- fish and Chinese, the interaction mode and quantitative relationship of the related molecules involved in B cell receptor signaling path-way were illustrated. By using Simulink'toolbox of Matlab7.0, a dynamic model of B cell receptor signaling pathway was developed and simulated. Results Model simulation results could reflect quantitatively the complex regulatory relationship among the interacting mole-cules involved in B cell receptor signaling pathway. In addition, model simulation could help to find and identify the key molecules in this signaling pathway. Conclusion Dynamic regulating of the reactivity of key molecules SYK and BTK controls the dynamics of B cell receptor signaling pathway.
Keywords：B cell receptorsignal transductiondynamic modelSYKBTK
Publication Date：2009-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 369-373 )