Role of CTLA-4 in induction of T cell anergy
Abstract：Objective To explore the role of CTLA-4 in the induction of T-cell anergy. Methods In the present study, we established an in vitro anergy model using superantigen SEA as the anergizing agents and examined CD28 and CTLA-4 expression of anergic T cells in response to SEA (Staphylococcal enterotoxin A) rechallenge. Results Anergic T cells express high level of CTLA-4 on the cell surface in the late stages of an immune response, but the level of CD28 expression is a little higher than that of activated T cells during whole immune response. Conclusions The enhanced cell surface expression of CTLA-4 is likely responsible for the induction of T cell anergy.
Keywords：T cellCTLA-4AnergySEA
Publication Date：2003-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 170-174 )