In v itro study on T cell proliferation inhibited by CTLA4Ig
Abstract：Objective To study the effects of CTLA4Ig on T cellproliferation. Methods T cell proliferation induced by phytohemagglutinin（PHA）， lipopolysaccharide（LPS） and staphylococcal enterotoxin B （SEB） with or without CTLA4Ig were detected by morphological changes and 3 H-TdR incorporation. Results PHA， LPS-induced T cell proliferation was inhibited by CTLA4Ig in a dose-dependent manner，while SEB-induced T cell proliferation was completely inhibited only when the dose of CTLA4Ig used reached to higher than 5 μg／mL.Conclusion CTLA4Ig could effectively inhibit T cell proliferation induced by PHA， LPS and SEB with different reaction models.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 210-212 )