Human anti-animal antibody and the interference in immunological assays
Abstract：Human anti-animal antibody response may result in some adversereaction interfere with antibodies from animal therapy or imaging，and cause both false-positive and false-negative test results in immunoassays Strategies to prevent the development of human anti-animal antibody responses include immunosuppressant therapy and the use of humanized，polyethylene glycolytated antibodies，or Fab fragment of antibody agents．Sample pretreatments or assay redesign can eliminate immunoassay interference caused by human anti-animal antibodies．Currently，several assays have been designed to detect human anti-animal antibodies．There are the assays available in kit form，even a simple point-of care test.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 69-71 )