Effect of female antisperm antibodies in serum and follicular fluid on in vitro fertilization-embryo transfer
Abstract：Objective To evaluate the effect of female antisperm antibodies（AsAb） on in vitro fertilization-embryo transfer（IVF-ET）. Methods Concentration of AsAb of serum and follicular fluid in women undergoing IVF-ET was measured with ELISA. Group A：13 women with AsAb positive in serum， Group B： 29 women with AsAb positive in serum and follicular fluid， Group C： 158 women with AsAb negative. The IVF rate， cleavage rate， early embryonic development as well as clinical pregnancy and abortion rate were analyzed and compared among the three groups respectively.Results The IVF rate and cleavage rate in group A and B decreased significantly as compared with group C （P＜0.01） . On the day of embryo transfer，Ⅰ—Ⅱgrade embryo rate in group A and B were significantly lower than that in group C.However，gradeⅣand 2PN embryo rates increased significantly as compared with group C （P＜0.05）. There were no significant difference in pregnancy and abortion rates among the three groups （P＞0.05）.Conclusion AsAb may exert a detrimental effect on IVF and early embryonic development， which can not be overcome completely by improving in vitro culture.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 58-59,68 )