Measurement of serum soluble Fas in patients with Graves’ disease and its clinical significance
Abstract：Objective To investigate the concentration of soluble sFas（sFas）in Graves’disease（GD） and its clinical significance.Methods Serum levels of sFas in 68 cases of GD patients and 20 cases of healthy subjects were measured with a sandwiched ELISA method.Results ①Serum sFas levels of GD untreated group and remission group were much higher than those of healthy controls（2.08±0.82， 1.11±0.31 vs 0.70±0.5 0 ng／mL，P＜0.001）；② Multiplier of sFas.TRAb in GD untreated group and remission group were much higher than those of healthy controls（80.01±57.62， 3.34±1.69 vs 0.81±0.80，P＜0.001）；③The concentration of serum sFas was significantly correlated with anti-thyrotropin（TSH） receptor antibody titers（r＝0.309，P＜0.05），but not with other clinical parameters（free triiodothyronine，free thyroxine and TSH）（r＝0.041—0.146，P＞0.05）.Conclusion Serum sFas may play a pivotal role in the pathogenesis of GD.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 56-57 )