Study of cellular multidrug resistant gene and apoptosis factor in peripheral blood and ovarian carcionoma cells in abdominal cavity infusion chemotherapy
Abstract：Objective To explore the multidrug resistant gene （Mdrl）expreession（P170） and cellular apoptosis of ovarian carcinoma in abdominal cavity infusion chemotherapy．Methods The samples of ascites cancer cells（ACC） were selectively collected in sixty-two primary and seventeen recurred ovarian carcinomas，immunologically marked by three kinds of fluorescent monoantibodies-P170（p-gp），CD95（Fas-Apo-1），Apo2．7，then determined by flow cytometry．Results ①The CD95 and Apo2．7 contents of ACC after chemotherapy were significantly higher than that before treatment（P＜0.05）；②The contents of P170 after chemotherapy were similar to that before treatment （P＜0.05）；③The P170 contents in recurred group were significantly higher than that found in the primary cancer group（P＜0.05），and the contents of CD95 and Apo2．7 in the recurred group after chemotherapy were lower than that in the primary group．④The CD95 contents of peripheral lymphocyte were also higher after abdominal cavity infusion chemotherapy（P＜0.05）．Conclusions The abdominal cavity infusion chemotherapy could obviously improve the apoptostic rate of ACC in ovarian carcinoma；but the apoptostic rate may decrease when the content of P170 becomes elevated．
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 53-55 )