Expression and clinical significance of CD3＋CD56＋ T cell in the peripheral blood on patients with malignant tumor
Abstract：Objective To study the relationship of CD3＋CD56＋ betweenCD3－CD56＋NK cells and CD3＋CD56－ T cells and anti-tumor activity of CD3＋CD56＋ T lymphocytes of patients with malignant tumor．Methods We analysed CD3－CD56＋，CD3＋CD56－，CD3＋CD56＋ T lymphocytes in blood samples of 100 patients（from 55 soft tumor patients and 45 non-soft tumor patients）and in 46 healthy control by flow cytometry．Results High expression of CD3＋CD56＋ in T cells was found both in soft tumor group and in non-soft one，there was significant difference between both the two groups and the control group（P＜0.01）．The expression of CD3＋CD56＋ T cells was much lower in soft tumor group than the non-soft tumor group and healthy control（P＜0.001），no significant difference was found in the expression of CD3－CD56＋NK cells among the three groups（P＞0.05）．Conclusion The CD3＋CD56＋expression was more abvious in the peripheral blood of patients with malignant tumor than CD3－CD56＋ NK cell．It was not influenced by the type of malignant tumor．It shows that the high expression of CD3＋CD56＋ T cells is one of the most important factors that make T lymphocytes to exert anti-tumor immunological function．
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 47-49 )