The signal transduction of protein kinase in PBLs co-stimulated by anti-CD28＋B7.1 McAb and the induction of apoptosis of the hepatoma cells
Abstract：Objective To investigate the activities of protein kinase C （PKC）and tyrosine protein kinase （TPK） in the activated and proliferating T cells and the induction of apoptosis of the hepatoma cells. Methods Healthy human PBLs were co-stimulated by anti-CD28 and anti-CD80 （B7.1） McAb and acted on the hepatoma cells （BEL-7402）. Results The activities of PKC and TPK were significantly higher in the activated T cells than those in the control cells， and were positively related to apoptosis of hepatoma cells. Conclusion PKC and TPK play important role on the signal transduction in the activated and proliferating T cells and the induction of apoptosis of hepatoma cells.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 40-42 )