Study on the effect of macrophage-myeloperoxidase in process of LDL oxidation
Abstract：Objective To investigate the effect of macrophage-myeloperoxidaseon LDL oxidation． Methods Based on the model of rat macrophage，we investigated the relation between macrophage-myeloperoxidase and LDL oxidation by measuring macrophage-myeloperoxidase activation，LDL oxidation products and cell cholesterol．Results LDL promoted cell and secretive myeloperoxidase activation which was concentration-dependent with LDL；with elevation of myeloperoxidase activation，LDL oxidation increased and NaN3 inhibited this effect；taurine partially protected against LDL oxidation by HOCl，and protected against accumulation of cell cholesterol．Conclusion LDL induced the elevation of macrophage-myeloperoxidase to enhance its own oxidation and absorption．
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 37-39 )