The effect of HBcAg/HBeAg on Th1/Th2 response in PBMC of chronic HBV infection patients
WANG Shao-yang
LIN Yu-mei
MA Wei-min
ZHANG Shu-lin
Abstract：Objective To explore the effect of HBcAg/HBeAg on Th1/Th2 response in PBMC of chronic HBV infection
patients. Methods HBV DNA in PBMC of 64 cases with chronic HBV infection were detected by nested polymerase chain re-
action. Thl-like cytokines (IL-2,IFN-γ) and Th2-like cytokines (IL-4,IL-10),produced by PBMC stimulated by PHA、
HBcAg、 HBeAg respectively,were measured by ELISA. Results There were no significant difference of both the levels of Th1-
like cytokines and the levels of Th2-like cytokines between HBV DNA positive group and HBV DNA negative group when
PBMCs were induced by PHA、HBcAg、HBeAg respectively. HBcAg-induced group and HBeAg-induced group were compared
with PHA-induced group,the Th1-like cytokines production was predominant when PBMC were stimulated by HBcAg; in
contrast,Th2-like cytokines production was predominant when PBMC were stimulated by HBeAg. Conclusions The results
suggested that HBVs invasion of PBMC did not affect the Thl/Th2 response; HBcAg and HBeAg could possibly affect the
production of Th1/Th2-like cytokines in PBMC of chronic HBV infection cases.
Keywords：Th1/Th2hepatitis B core antigen(HBcAg) Hepatitis B e antigen(HBeAg)peripheral blood mononuclear cell(PBMC)
Publication Date：2000-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 451-453 )