The influence of immunosuppressive therapy on titers of anticardiolipin antibodies in systemic lupus erythematosus
LIU Gang
WANG Lan-lan
ZHANG Rui-wei
WANG Zhong-Ming
XIE Qi-bing
Abstract：Objective To observe the prevalence and clinical association of anticardiolipin antibodies(ACA)and the in-
fluence of immunosuppressive therapy on titers of ACA in systemic lupus erythematosus (SLE). Methods ACA(IgG, IgA,
IgM)was measured by enzyme-linked immunosorbent assay(ELISA)in the serum sample of 87 patients of SLE. 17 cases of
SLE had been tested on admission and 3 months after treatment with immunosuppressive therapy . Results The prevalence of
ACAIgG,ACAIgA ,ACAIgM was respectively 62.1%,52.9%,35.6% in SLE. The titers of ACAIgG and ACAIgM were sig-
nificantly and positively correlated with disease activity;ACAIgG,ACAIgA and ACAIgM were significantly and negatively
correlated with complement C3 ,ACAIgG was significantly and negatively correlated with complement C4. With thrombosis,the
titers of ACAIgA were higher than those without thrombosis. Among the patients with central nervous system involvement
(CNS-SLE),ACAIgG and ACAIgM titers were significantly higher than those without CNS-SLE. There is a significant differ-
ence between the means of ACA titers of 17 SLE on admission and three months after treatment. Conclusions ACA titers
were positively correlated with disease activity. With thrombosis, the titers of ACAIgA were higher. With CNS-SLE,ACAIgG
and ACAIgM titers were higher. Immunosuppressive therapy decreases the ACA titers of SLE.
Keywords：anticardiolipin antibodysystemic lupus erythematosusimmunosuppressive therapy
Publication Date：2000-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 445-447 )