The value of detecting laminin and collagen IV in sera of patients with connective tissue disease
XU Sheng-qian
WANG Fen
LIU Gong-zhuan
Abstract：Objective To explore the clinical significance of laminin(LN) and collagen IV(IV·C) in sera of patients
with rheumatoid arthritis(RA),systemic lupus erythematosus(SLE) and other connective tissue diseases(CTD). Methods A
sensitive radioimmunoassay was utilized to detect the level of IV·C and LN in sera of 36 patients with RA, 34 with SLE,
17 with CTD and 63 normal individuals. Results The level of IV·C and LN elevated significantly in RA,SLE and CTD(P＜
0.01～0. 0001)and the level of LN in SLE was obviously higher than that in RA(P＜0.05). There is a positive correlation be-
tween serum IV·C and erythrocyte sedimentation rate(P＜0.05),a negative correlation between serum LN and albumin(P＜
0. 005 ),a positive correlation between serum LN and globulin, complement C3 (P＜0.05～0. 001 ). Conclusion Serum IV· C
and LN may be considered as an important reference factor in evaluating the activity of connective tissue disease and become
immunopathogenic in developing progress of connective tissue disease.
Keywords：collagenlamininarthritisrheumatoidlupus erythematosussystemic
Publication Date：2000-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 442-444 )