Evaluation on the interrelationship between serum sPTA1 level and allograft acute rejection in living-related small bowel transplantation
Dong Guang-long
WANG Wei-zhong
WU Guo-sheng
Song Wei-liang
LI Kai-zong
JA Wei
JIN Bo-quan
Abstract：Objective To study the interrelationship between the changes in serum sPTA1 level and the acute small
bowel allograft rejection in the first case of living-related small bowel transplantation in China. Methods It was the first time
that solid-phase double ligand ELISA method was used to analyzed serum level of sPTA1. Results Allograft acute rejection
occurred on the 67th day. sPTA1 serum level increased two weeks before the rejection and reached to 60.49 ng/mL at the 5th
day,peaked at one day before rejection to 71.64 ng/mL,then decreased quickly to the preoperation level on the second day of
rejection with more immunosuppressive agent. Conclusions The activation of infiltration T cell in the allograft of living-relat-
ed small bowel transplantation was a gradual process. The allograft did not show signs of acute rejection to the naked eye
and/or histopathological changes under the microscope until the activation reached to a certain level (two times more than that
of preoperation). Moreover,the changes of the serum sPTA1 level occurred earlier than that in histopathology.
Keywords：living-related small bowel transplantationsPTA1acute rejection
Publication Date：2000-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 439-441 )