Anticancer Activity of The 1,3-Oxazacyclohexane Alkaloid A, B from Celastrus Angulatus
YIN Wei-Ping
ZHAO Tian-Zeng
GAO Ling-Jie
Abstract：Two new alkaloids A, B identified as 1,3-oxazacyclohexane skeleton were isolated from the seeds of Celastrus angulatus. Previous studies were focus on the sesquiterpene poloyol esters and sesquiterpene alkaloids from this family plants, which we have reported the separation and structural elucidation of two new alkaloids A, B from the same plant in recent days. Their structures were respectivily identified as 2α-(2'-pyrrolyl)-4α-methoxycarbony1-1, 3-oxazacyclohexane (A) and 2α-(2'-pyrrolyl)-4α-methoxycarbonyl-5β-[(2"-methyl)-hepty1]-1, 3-oxazacyclohexane (B). The compound B demonstrated moderate cytotoxicity against non-small lung cancer (NCL-H23) cell line by the National Cancer Institute in vitro cytotoxicity screen.
Keywords：Celastrus angulatus13-oxazacyclohexaneNew skeleton compoundAnticancer activity
Publication Date：2000-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 67-69 )