Application progress of the multidisciplinary collaborative diagnosis and treatment model in unresect-able hepatocellular carcinoma
LIAO Xiaojian
LIAO Yuejun
LU Xianzhou
Abstract：Unresectable hepatocellular carcinoma(u-HCC)is a global challenge in cancer treatment,and its patho-genesis is mainly associated with chronic hepatitis B,chronic hepatitis C,and non-alcoholic fatty liver disease and other diseases.Traditional single-discipline diagnosis and treatment often fail to comprehensively access tumor burden,liver function reserve,and the overall condition of patients,resulting in limited therapeutic effects.The multidisciplinary team(MDT)model integrates resources from multiple departments,including surgery,medical oncology,interventional radiolo-gy,radiology,pathology and hepatology,to promote personalized full process management.Existing evidence has showed that MDT could significantly prolong the median overall survival of patients,improve the conversion resection rate,and re-duce treatment-related adverse events.It also has clear benefits for high-risk subgroups such as portal vein thrombosis,Child-Pugh grade B,and elderly patients.MDT is not only a leading diagnostic and treatment model widely respected in the modern international medical field,but also provides a reference for the diagnosis and treatment of complex tumors.However,the clinical popularization of MDT still faces challenges such as uneven resource distribution,lack of standards,and insufficient policy support.In the future,efforts should be made to build a precise decision-making system based on multi-omics and artificial intelligence,establish a full-cycle management pathway,and promote regional and international practices under a unified framework.
Keywords：unresectable hepatocellular carcinomamultidisciplinary teamconversion therapyclinical pathwaysurvival outcomeprecision medicine
Publication Date：2025-12-25
Online Publishing Date：2026-01-09(First online date of this platform, not the publication date of the document)
Pages：6( 80-85 )