Exploring the causal relationship between rheumatoid arthritis and type 2 diabetes using two-sample Mendelian randomization
SHI Yida
CHEN Xiaomeng
LI Jin
Abstract：Objective To explore the causal relationship between rheumatoid arthritis and the risk of developing type 2 diabetes using two-sample Mendelian randomization.Methods Two-sample Mendelian randomization analysis was performed based on genome-wide association analysis(GWAS)data with single nucleotide polymorphism(SNP)as in-strumental variable,rheumatoid arthritis as the exposure,and type 2 diabetes as the outcome.The primary analysis meth-od was inverse variance weighting(IVW),the F statistic was calculated toaccess the stability of instrumental variables,and Cochran's Q statistic was used to test the heterogeneity among instrumental variables.Sensitivity analyses were con-ducted using MR-Egger regression,weighted median method(WME),simple mode-based estimation,and weighted mode-based estimation.Results A total of 30 SNPs were selected as instrumental variables.The IVW method indicated a positive causal relationship between rheumatoid arthritis and type 2 diabetes(OR=1.05,95%CI:1.01-1.08,P=0.006).The results of the heterogeneity test showed that there was no heterogeneity in the causal relationship between rheumatoid arthritis and type 2 diabetes(P>0.05).The results of the horizontal pleiotropy test showed that there was no ef-fect of horizontal pleiotropy on rheumatoid arthritis and type 2 diabetes(P>0.05).The results of the MR analysis pos-sessed good stability and did not have significant publication bias.Conclusion There is a positive causal relationship be-tween rheumatoid arthritis and the development of type 2 diabetes.
Keywords：rheumatoid arthritistype 2 diabetesMendelian randomizationgenome-wide association studycaus-al relationship
Publication Date：2025-08-25
Online Publishing Date：2025-09-17(First online date of this platform, not the publication date of the document)
Pages：4( 41-44 )