The predictive value of serum CRP,IL-6 and BNP levelsin elderly patients with chronic heart failure complicated with pulmonary infection
LIU Yalin
WANG Feng
Abstract：Objective To investigate the predictive value of serum C-reactive protein(CRP),Interleukin-6(IL-6)combined with B-type natriuretic peptide(BNP)in elderly patients with chronic heart failure complicated with pulmonary infection.Methods A total of 112 elderly patients with chronic heart failure admitted to Xi'an People's Hospital(Xi'an Fourth Hospital)from January 2022 to June 2023 were selected and divided into aninfected group(n=46)and an uninfect-ed group(n=66)according to whether they had a concurrent pulmonary infection.The general case data and the number of cases with hypoproteinemia,anemia,abnormal transaminase,renal insufficiency,as well as the levels of CRP,IL-6 and BNP indices of the patients in the two groups were compared with each other.Logistic regression was used to analyze the in-fluencing factors of pulmonary infection in elderly patients with chronic heart failure.The receiver operating characteristic(ROC)curve was plotted to analyze the efficacy of CRP,IL-6 and BNP in predicting pulmonary infection in elderly pa-tients with chronic heart failure.Results The levels of serum CRP(OR=1.068,95%CI:1.011-1.127,P=0.018),IL-6(OR=1.153,95%CI:1.032-1.287,P=0.012),BNP(OR=1.007,95%CI:1.001-1.014,P=0.018)were influ-encing factors for pulmonary infection in elderly patients with chronic heart failure.The ROC curve analysis showed that the areas under the ROC curve for CRP,IL-6,BNP,and their combination in predicting the occurrence of pulmonary in-fection in elderly patients with chronic heart failure were 0.910,0.910,0.647,and 0.939 respectively,with sensitivities of 73.90%,82.60%,50.00%,and 84.80%respectively,and specificities of 92.40%,87.90%,78.80%,and 93.90%respectively.Conclusions The levels of serum CRP,IL-6 and BNP are influencing factors for pulmonary infec-tion in elderly patients with chronic heart failure.The combined detection of these three indicators has predictive value for the occurrence of pulmonary infection in elderly patients with chronic heart failure.
Keywords：B-type natriuretic peptideC-reactive proteininterleukin-6chronic heart failurepulmonary infec-tion
Publication Date：2025-08-25
Online Publishing Date：2025-09-17(First online date of this platform, not the publication date of the document)
Pages：5( 5-9 )