Analysis of lymphocyte subsets in peripheral blood of patients with rheumatoid arthritis
HAO Tiantian
CHEN Hongxia
TANG Zizheng
XIE Kangqi
WANG Hui
Abstract：Objective To investigate the changes of lymphocyte subsets in peripheral blood of patients with rheuma-toid arthritis(RA).Methods Peripheral venous blood was collected from 45 RA patients(RA group)and 36 healthy subjects during the same period(control group)admitted to the Fourth People's Hospital of Jinan from January 2024 to Jan-uary 2025.Lymphocyte subsets(T lymphocytes,B lymphocytes and NK cells),T lymphocyte subsets(CD4+and CD8+)and CD4+T lymphocyte subsets(Th1,Th2,Th17 and Treg)in the two groups were detected by flow cytometry and com-pared between the two groups.Results Compared with the control group,the levels of NK cells,CD4+T lymphocytes,CD4+/CD8+and Treg cells in the peripheral blood of the RA group were down-regulated(all P<0.05).The levels of B lym-phocytes,Th1 cells,Th1/Th2 and Th17/Treg were up-regulated(all P<0.05).Conclusion Peripheral blood lympho-cyte subsets are disordered in RA patients.
Keywords：rheumatoid arthritisperipheral bloodcellular immunitylymphocyte subpopulation
Publication Date：2025-06-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 15-18 )