Research progress of NLRP3 inflammasome in postoperative ileus
LI Xing
CHEN Qicheng
CAO Lixing
JIANG Zhi
Abstract：Postoperative ileus(POI)is a very common and potentially serious iatrogenic gastrointestinal motility disor-der after surgery.If there is a delay in the recovery of gastrointestinal motility after surgery,it can lead to internal environ-ment disorders,malnutrition,and infection,which increase the risk of other severe complications.NLRP3 inflammasome is an important component of the innate immune system,mediating the activation of Caspase-1 and the secretion of pro-in-flammatory cytokines IL-1β/IL-18 in response to microbial infection and cell damage.NLRP3 inflammasome may play a role in POI through various mechanisms,such as regulating inflammatory responses,constructing a neuroinflammatory en-vironment,affecting gut microbiota balance,and inducing pyroptosis.Moreover,NLRP3 inflammasome is expected to serve as a new therapeutic target,which can improve POI by acting on NLRP3 inflammasome.
Keywords：NLRP3 inflammasomepostoperative reactioninflammatory responseimmune responsetherapeu-tic target
Publication Date：2025-02-24
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 63-67 )