The impact of end-tidal carbon dioxide levels during the operation on postoperative nausea and vomit-ing in elderly patients undergoing gynecological laparoscopic surgery
WANG Mingyu
HENG Lei
Abstract：Objective To investigate the impact of intraoperative end-tidal carbon dioxide(EtCO2)levels on postop-erative nausea and vomiting(PONV)in elderly patients undergoing gynecological laparoscopic surgery.Methods A to-tal of 197 elderly patients who were treated at Xuzhou Maternity and Child Health Hospital and underwent gynecological laparoscopic surgery from January 2023 to October 2024 were included.Data were collected through the ward doctor sys-tem,and intraoperative EtCO2 was continuously monitored using a sidestream gas analyzer,and recorded through the anes-thesia information management system.The cases were divided into EtCO2≤45 mmHg and EtCO2>45 mmHg.Primary out-come indicator(PONV)and secondary outcome indicators(nausea,vomiting,postoperative blood transfusion,postopera-tive hospitalization days,hospitalization costs,surgical site infection,reoperation,wound bleeding,bleeding,hemato-ma)were observed 2 days after surgery.Multivariate logistic regression analysis was used to identify independent risk fac-tors of PONV in elderly patients undergoing gynecological laparoscopic surgery and investigate the relationship between EtCO2 level and PONV in elderly patients undergoing gynecological laparoscopic surgery.Results Multivariate logistic regression analysis revealed that average intraoperative EtCO2>45 mmHg(OR=4.637,95%CI:2.414-8.906,P<0.001)was an independent risk factor for PONV in elderly patients undergoing gynecological laparoscopic surgery within two days post-surgery.Among the 122 patients with an average intraoperative EtCO2>45 mmHg,83 experienced PONV within two postoperative days,significantly higher than the 23 patients with average EtCO2≤45 mmHg(P<0.05).Conclusion Av-erage intraoperative EtCO2>45 mmHg is an independent risk factor for PONV within two days post-surgery in elderly pa-tients undergoing gynecological laparoscopic surgery.
Keywords：end-tidal carbon dioxidepostoperative nausea and vomitinglaparoscopic surgeryaged
Publication Date：2025-02-24
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 20-23 )