Based on Nomogram model predicting the risk of adjacent vertebral fractures after bilateral vertebro-plasty
CUI Shanlin
CHEN Yongxi
LIU Kedi
FAN Junhong
QIN Zhongshe
GUO Shenghui
MENG Juewei
LI Pinyuan
Abstract：Objective To explore the influencing factors of adjacent vertebral fractures(AVCF)in patients with os-teoporotic vertebral compression fractures(OVCF)after percutaneous vertebroplasty(PVP),and construct a Nomogram prediction model.Methods A total of 174 patients after bilateral PVP who had suffered from OVCF and hospitalized in Spinal Surgery Department of the First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine from Au-gust 2019 to August 2022 were selected.According to whether there was a new occurrence of postoperative AVCF,pa-tients were divided into those with fractures and those without fractures.LASSO regression and binary logistic regression were used to analysis risk factors for AVCF in OVCF patients after bilateral PVP.R Studio was applied to construct a No-mogram prediction model,and its predictive performance was evaluated.Results There were 47 cases of AVCF and 127 cases of no fractures in OVCF patients after bilateral PVP.LASSO regression and binary logistic regression analysis showed that BMI,preoperative vertebral compression ratio,postoperative vertebral recovery ratio,postoperative Cobb an-gle correction,lumbar bone density,and bone cement leakage were independent risk factors for AVCF after bilateral PVP for OVCF.Subsequently,the six independent risk factors mentioned above was used to construct a Nomogram prediction model.The area under the working characteristic curve of the model subjects was 0.838(95%CI:0.679-0.875).The Bootstrap method was used to validate the internal performance of the model,and the results showed that the model's pre-dictions were consistent with the actual situation(C-index of 0.838).Conclusions Bone cement leakage,preoperative vertebral compression ratio,low BMI,Cobb angle correction of the injured vertebra,lumbar spine bone density,and post-operative vertebral recovery ratio are risk factors for AVCF after bilateral PVP.The Nomogram model based on the above risk factors can provide some reference for prevention and treatment of AVCF after bilateral PVP for OVCF.
Keywords：osteoporotic vertebral compression fracturespercutaneous vertebroplastyadjacent vertebral compres-sion fracturesrisk factor model
Publication Date：2023-12-25
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 1-5 )