Effect of sitagliptin-metformin combined with nifedipine on blood pressure,blood glucose,and vascular endothelial function in patients with hypertension and type 2 diabetes mellitus
YANG Li-fei
Abstract：Background The co-existence of Type 2 diabetes mellitus (T2DM) and hypertension presents a significant clinical challenge due to their synergistic detrimental effects on cardiovascular outcomes. Conventional combination therapies often fall short in comprehensively addressing the intertwined pathophysiologies, particularly vascular endothelial dysfunction. This study aimed to evaluate the efficacy of a novel regimen combining sitagliptin-metformin with nifedipine in managing blood pressure, blood glucose, and vascular function in this high-risk population. Methods 150 patients with T2DM and hypertension were randomly assigned to either the control group (n=75) treated with metformin and nifedipine, or the experimental group (n=75) treated with sitagliptin-metformin compound preparation combined with nifedipine. Changes in blood pressure, blood glucose levels, flow-mediated dilation (FMD) and nitroglycerin-mediated dilation (NMD) of the brachial artery, and serum levels of biomarkers [nitric oxide (NO), endothelin-1 (ET-1)] were compared before and after treatment. The incidence of adverse reactions during treatment was also monitored. Results After treatment, both groups showed significant reductions in blood pressure, blood glucose parameters, and ET-1 levels compared to baseline. The experimental group demonstrated significantly lower values in these assessments at the same time points than the control group (P<0.05). Conversely, FMD, NMD, and NO levels increased significantly in both groups after treatment, with the experimental group showing significantly higher values than the control group (P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusions The combination of sitagliptin-metformin compound preparation and nifedipine significantly enhanced blood pressure control and blood glucose control and exerted a positive regulatory effect on vascular endothelial function in patients with T2DM and hypertension, demonstrating high clinical value for widespread application. [S Chin J Cardiol 2025;26(4):276-283]
Keywords：Sitagliptin-metformin compound preparationNifedipineHypertensionType 2 diabetes mellitusBlood pressureBlood glucoseVascular endothelial function
Publication Date：2025-12-30
Online Publishing Date：2026-01-27(First online date of this platform, not the publication date of the document)
Pages：8( 276-283 )