Mitral valve regurgitant area as an independent predictor of in-hospital mortality in elderly patients with dilated car-diomyopathy
ZHANG Zi-yi
LI Xin-yi
WANG Jia-qi
GONG Jian-tao
TAN Ning
TSANG Suk-Ying
WONG Wing-tak
JIANG Lei
Abstract：Background: Predicting in-hospital mortality in elderly patients with dilated cardiomyopathy (DCM) is critical for improving clinical management. This study investigated the prognostic significance of mitral valve regurgitant area (MVRA) as a predictor of in-hospital mortality. Methods: A total of 813 elderly patients (age ≥60 years) diagnosed with DCM were included in this retrospective study, with admissions spanning from January 2010 to December 2019. Univariate and multivariate Cox regression analyses were conducted to assess the association between MVRA and in-hospital mortality. Receiver operating characteristic (ROC) curve and Kaplan-Meier survival analyses were employed to assess the predictive performance of MVRA and to compare cumulative survival rates between groups, respectively. Results: MVRA was significantly associated with in-hospital mortality in both univariate and multivariate analyses (HR: 1.119, 95% CI: 1.028-1.218, P=0.009). ROC curve analysis demonstrated good prognostic performance for MVRA [area under curve (AUC): 0.714]. Kaplan-Meier analysis revealed that patients with high MVRA (HMVRA) had significantly worse in-hospital survival outcomes (log-rank χ2=12.628, P<0.001). Conclusions: An increase in MVRA is significantly associated with higher in-hospital mortality in elderly DCM patients, with an MVRA exceeding 7 cm2 indicating a notably increased mortality rate. MVRA serves as a simple and effective parameter for risk assessment and treatment monitoring in DCM patients.
Keywords：In-hospital mortalityDilated cardiomyopathyElderly patientsMitral regurgitationRisk predic-tion
Publication Date：2025-03-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：7( 42-48 )