Triglyceride-glucose index is associated with in-hospital pulmonary infection and bleeding in patients with ST-seg-ment elevation myocardial infarction undergoing percuta-neous coronary intervention
ZENG Lin
JIN Wei-zhen
ZHEN Ci-en
YANG Man
LI Yu
PENG Shi-min
XIE Li-xin
DUAN Chong-yang
LIU Yuan-hui
SUN Zhong-chan
ZHUANG Yan
HE Peng-cheng
Abstract：Background The triglyceride-glucose (TyG) index has been widely studied in metabolic and cardiovascular diseases. ST-segment elevation myocardial infarction (STEMI) patients undergoing percutaneous coronary intervention (PCI) are at increased risk of pulmonary infection due to their stressful conditions. While previous studies have confirmed the predictive role of TyG index in the prognosis of STEMI patients, its potential association with pulmonary infection remains unclear. This study was to explore the relationship between the TyG index and pulmonary infection in STEMI patients undergoing PCI. Methods STEMI patients who underwent PCI were enrolled and stratified into three tertiles based on the TyG index measured after receiving PCI. Primary outcome was pulmonary infection during hospitalization. Secondary outcomes were in-hospital bleeding, all-cause mortality and major adverse cardiac events (MACE) as well as MACE during follow-up. Logistic regression and Cox proportional hazard regression were mainly used to estimate outcomes. Results 3652 patients were enrolled in this study. In multivariate logistic regression, the TyG index was associated with in-hospital pulmonary infection [adjusted odds ratio (aOR): 1.29, 95% CI: 1.05-1.58, P=0.014], mortality (aOR: 2.27, 95% CI: 1.64-3.15, P<0.001), MACE (aOR: 1.81, 95% CI: 1.39-2.37, P<0.001), and any bleeding (aOR: 1.22, 95% CI: 1.04-1.43, P=0.013). The median follow-up was 1.70 years. After adjusting for potential confounders, the TyG index was positively related to long-term MACE (aHR: 1.26, 95% CI: 1.06-1.49, P=0.009). Conclusions A high TyG index was associated with in-hospital pulmonary infection, bleeding, mortality and MACE in patients with STEMI undergoing PCI. Additionally, it is also associated with long-term MACE. [S Chin J Cardiol 2025;26(1):9-20]
Keywords：Pulmonary infectionHemorrhageTriglyceride-glucose indexAcute myocardial infarction
Publication Date：2025-03-30
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：13( 9-20,35 )