Safety evaluation and effects of Lactobacillus reuteri YL006 on growth performance and antioxidant capacity of mice
Ju Minying
Zhang Zenglian
Zhang Yanfen
Ma Zipeng
Sun Yuming
Bai Chongsheng
Guo Wenqing
Han Bin
Abstract：The aim of this study was to investigate the safety of Lactobacillus reuteri YL006 and its effects on growth performance and antioxidant capacity of animals,so as to provide reference for its application as feed additive in livestock and poultry breeding.A Lactobacillus reuteri YL006 strain was isolated from the intestinal tract of piglets.The safety,growth promotion and antioxidant effects of Lactobacillus reuteri YL006 were investigated by acute toxicity test,subacute toxicity test,bacterial migration test and antioxidant index determination.The results showed that:After 7 days of acute toxicity test,the experimental group and control group mice did not die,all life activities were normal,weight gain was not obvious,anatomy was not abnormal,no bacterial migration phenomenon.The results of subacute test for 28 days showed that all mice in each group survived normally and no bacterial migration occurred,which proved the safety of the bacteria.The body weight and average daily gain of mice in the medium dose group(107 CFU/mL)were significantly higher than those in other groups(P<0.05).The serum total antioxidant power(T-AOC),total superoxide dismutase(T-SOD)and glutathione peroxidase(GSH-Px)activities of experimental groups were significantly higher than those of the control group(P<0.05),and the serum malondialdehyde(MDA)content of experimental groups was significantly lower than that of the control group(P<0.05).The results showed that the growth performance and antioxidant capacity of mice were improved by administration of Lactobacillus reuteri YL006 solution,and the best effect was achieved when the dose was 107 CFU/mL.
Keywords：Lactobacillus reuteriAcute toxicity testSubacute toxicity testSafety evaluationGrowth performanceAntioxidant capacity
Publication Date：2024-12-15
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 33-37 )