Selection and optimization of thermostable agent for Newcastle Disease and Infectious Bronchitis bivalent vaccine
Chen Shenglei
Li Fengyan
Gao Hongxia
Li Yi
Wang Yan
Shu Xiuwei
Abstract：In this paper, we tested protective effects of 7 groups of the lyoprotectant recipe for Newcastle Disease and Infectious Bronchitis Vaccine, Live Vaccine (La Sota strain + H120 strain) were used for cross reference by an accelerated stability test. The best lyoprotectant rec-ipe of Newcastle-Bronchitis Vaccine had been screened in this experiment, and the results indicat-ed that when exposure this lyoprotectant vaccine at 37 ℃ for 10 days, or exposure at 25 ℃ for 30 days, the vaccine virus titers declined by 0.4 unit or 0.4~0.6 unit respectively, while other lyo-protectant vaccines virus titers decreased by 2~2.4 unit or 1.8~2.6 unit respectively. In conclu-sion, the new lyoprotectant showed effective protection for Newcastle-Bronchitis Vaccine.
Keywords：Live vaccineThermostable agentThermostablility test
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1-4 )