Determination of Ribavirin in Feeds and chicken by Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry
Liu Kai
Wang Lina
Li Jianzhong
Abstract：A method of Ultra Performance Liquid Chromatography-Tandem mass spectrometry(UPLC-MS/MS) for determination of ribavirin in feeds and chicken was developed. The drugs were extracted with acetonitrile/trichloroacetic acid from analyte, then cleaned up with PBA cartridges. The elu-ent was assayed by UPLC-MS/MS. The detection and quantification limits were 25.0 μg/kg and 50.0 μg/kg respectively. The average recoveries were 90.0%~114.5%. The real sample tests showed this meth-od can be used for the sensitive and accurate determination of ribavirin in feeds and chicken.
Keywords：RibavirinFeedsChickenUPLC/MS/MS
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 15-19 )