Optimization of Preparation Technology and Quality Control of Compound Radix Bupleuri Extract Hollow Suppository
Li Li
Li Lu
Wang Jinli
Abstract：Compound Bupleurum extract hollow bolt was prepared from Radix Bupleuri Extract and Flunixin Meglumine which were used as main drug, and mixture of Semi-synthetic fatty acid alycer-ide and Polyethylene glycol were selected as ground substance. Hollow type suppository preparation was selected in the orthogonal experiment with the examined factors of the proportion of the drug and the ground substance(A), Liquid temperature(B), and Stripping time(C) and the indexes of out-ward appearance and melt time, and the quality was checked according to China Veterinary Pharmaco-poeia. The results show that the optimum preparation of suppository is A2B2C2, the optimum propor-tion of synthesis fatty acid is 1:2. the liquid temperature is 50℃, and the stripping time is 25 min. The total saikosaponins content is stable in suppository, the optimum preparation of supposi-tory is feasible, so the method is suitable to be used in large-scale production.
Keywords：Radix Bupleuri ExtractHollow Type SuppositoryPreparation ProcessQuality Con-trol
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：5( 5-9 )