Synergistic Effects of Taurine and L-Arginine on the levels of ACE and AngⅡof Insulin Resistance Hypertensive Rats
Li Jitao
Hu Jianmin
Liang Weiwei
Gao Yongchao
Feng Ying
Abstract：To elucidate the synergistic effects of taurine and L-arginine on hypertension, 25%fructose were administered to male Wistar rats for 12 weeks to establish insulin resistance hyper-tensive models. Rats with the systolic blood pressure(SBP) higher than 150 mmHg were considered as model rats. Forty-two model rats were randomly divided into six groups and administered with 3% taurine, 3% L-arginine, 2.7% taurine+0.3% L-arginine, 2.1% taurine+0.9% L-arginine and 1.5%taurine+1.5% L-arginine in drinking water respectively. The results showed that coadministration of taurine(1.5%) and L-arginine(1.5%) could bring the levels of SBP, blood glucose, ACE and AngⅡdown to normal levels after 4 weeks. These data indicated that both taurine and L-arginine could ameliorate vascular remodeling and showed obvious antihypertesive effects, and taurine(1.5%) and L-arginine(1.5%)in drinking water showed a better result in the cure of hypertension.
Keywords：TaurineL-arginineInsulin-resistanceHypertension
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 1-4 )