A preliminary evaluation of the clinical efficacy of a sebum-regulating and balancing acid complex in the treatment of scalp seborrheic dermatitis:A single-arm,open-label study
WANG Youyu
WANG Haihong
ZHANG Shaoqin
JIANG Leiwei
Abstract：Objective To evaluate the clinical efficacy,safety,and mechanisms of a sebum-regulating and balancing acid complex in treating scalp seborrheic dermatitis(SSD).Methods Thirty eligible SSD patients were enrolled in this single-arm,open-label,self-controlled study.The intervention consisted of four weekly scalp acid peeling sessions.Subjective symptoms(oili-ness,itching,pain)were self-assessed by patients,while clinical signs(erythema,papules,scales)were evaluated by investigators via dermoscopy before each treatment.Fungal fluorescence staining of scalp scales was performed at baseline and post-treatment.Patients were followed up weekly for four weeks,starting two weeks after the last session.Results After four treatments,the subjective symptom scores(greasy sensation,itching,pain)and clinical sign scores(erythe-ma,scaling,papules)of the subjects significantly decreased(P＜0.01).The overall effective rate was 96.7%.Among the 27 patients who tested positive for fungi at baseline,12(44.44%)achieved complete fungal clearance after treatment.During the treatment period,two patients ex-perienced transient mild itching of the scalp and fever,which resolved spontaneously after 30 mi-nutes of observation,with no serious adverse reactions reported.During the 4-week follow-up,symptom and sign scores showed no significant changes(P＞0.05),except for a further improve-ment in erythema.Conclusions The compound acid treatment significantly ameliorates symptoms such as greasiness,itching,and pain in patients with SSD,as well as signs like erythema,pap-ules,and scales,while demonstrating good safety.
Keywords：scalp seborrheic dermatitissebum-regulating and balancing acid complexscalp barriermicrobial barriersingle-arm study
Publication Date：2026-01-28
Online Publishing Date：2026-03-11(First online date of this platform, not the publication date of the document)
Pages：7( 9-15 )