Clinical observation on Liangxue Xiaoban Granules combined with conventional western medicine in treating psoriasis of blood-heat and wind-dryness type
LI Ruiting
ZHAO Meng
LIU Yan
LI Jing
ZHANG Junpeng
Abstract：Objective To evaluate the clinical efficacy and safety of Liangxue Xiaoban Gran-ules combined with conventional western medicine in treating psoriasis of blood-heat and wind-dry-ness type,and to explore its effects on inflammatory cytokines.Methods Ninety psoriatic pa-tients were randomly assigned to a control group(n=45)and an observation group(n=45).The control group received the standardized conventional western medicine,while the observation group was given Liangxue Xiaoban Granules in addition to the conventional treatment.After 12 weeks of treatment,outcomes were compared between the two groups,including the overall re-sponse rate,psoriasis area and severity index(PASI)score,traditional Chinese medicine(TCM)syndrome score,and the adverse reaction rates.Additionally,serum levels of interleukin-2(IL-2),interleukin-6(IL-6),interleukin-8(IL-8),and interferon-gamma(IFN-γ)were compared.Results After 12 weeks of treatment,the total effective rate was significantly higher in the obser-vation group than in the control group(97.62％vs.83.72％,P＜0.05).Compared to the con-trol group,the observation group demonstrated greater reductions in PASI score,TCM syndrome scores(generalized erythema,pruritus,dryness and scaling),and serum levels of IL-2,IL-6,IL-8,and IFN-γ(all P＜0.05 vs.the controls).No severe adverse reactions were observed in any patients during the treatment period.Conclusions The combination therapy of Liangxue Xi-aoban Granules and conventional Western medicine is safe and effective.It can significantly allevi-ate skin lesions,reduce inflammatory irritation,and improve TCM syndrome in psoriatic patients of blood-heat and wind-dryness type.
Keywords：psoriasisLiangxue Xiaoban GranulesTCM syndromeinflammatory irrita-tion
Publication Date：2025-10-28
Online Publishing Date：2025-11-20(First online date of this platform, not the publication date of the document)
Pages：7( 715-721 )