Update on the treatment of neutrophilic dermatoses
MENG Yongxia
NIU Lulu
CHEN Huajun
CHEN Mukai
Abstract：Neutrophilic dermatoses(NDs)are a group of non-infectious inflammatory disorders characterized by aseptic neutrophilic infiltration.Pro-inflammatory cytokines,including IL-1 β,IL-17,and TNF-α,play pivotal roles in the pathogenesis of these conditions.Although glucocorti-coids and immunosuppressive agents still serve as the primary treatment modalities,biologics and small molecule targeted therapies have become a major focus of recent research.This article re-views the recent advances in the application of such emerging drugs for the treatment of NDs,in-cluding the mechanisms of action and clinical efficacy of TNF-α inhibitors,IL-1 inhibitors,and other biologics.It also evaluates the level of evidence from relevant literature,aiming to provide a reference for the clinical management of refractory and recurrent neutrophilic dermatoses.
Keywords：neutrophilic dermatosespathogenesistreatmentbiologics
Publication Date：2025-09-28
Online Publishing Date：2025-10-29(First online date of this platform, not the publication date of the document)
Pages：8( 679-686 )