New advances in the treatment of cutaneous basal cell carcinoma
ZHANG Yuanlin
MENG Xiumei
CI Chao
Abstract：As the most common malignant skin tumor,the incidence of basal cell carcinoma(BCC)is rising with population aging.Although most cases are localized,a small number may in-filtrate or metastasize,making early diagnosis and treatment crucial.This article reviews recent advances in the treatment of cutaneous BCC,highlighting the characteristics and latest develop-ments of various therapeutic approaches.These include Mohs micrographic surgery,photodynamic therapy,cryotherapy,topical medications such as imiquimod,5-fluorouracil(5-FU),ingenol mebutate(IM),radiotherapy,laser therapy,targeted drug therapies such as Hedgehog pathway inhibitors(HPI),and programmed death receptor-1(PD-1)inhibitors.Emerging treatments such as oncolytic peptides and small interfering RNA(siRNA)drugs are also discussed.The article emphasizes the importance of tailoring treatment strategies based on BCC risk levels and suggests that future therapies will focus more on technological innovation and multidisciplinary collaboration to improve patient outcomes and quality of life.
Keywords：basal cell carcinomamohs surgeryHh pathway inhibitorsPD-1 inhibitors
Publication Date：2025-08-28
Online Publishing Date：2025-09-23(First online date of this platform, not the publication date of the document)
Pages：6( 613-618 )