Advances in psychiatric comorbidity in atopic dermatitis:pathogenesis and therapy
LIU Tingyu
SHEN Chen
FENG Aiping
Abstract：Atopic dermatitis(AD),a chronic inflammatory skin disease,has been widely rec-ognized to exhibit significant associations with various mental health disorders.Epidemiological ev-idence indicates that AD patients face substantially increased risks of psychiatric comorbidities such as anxiety,depression,suicidal tendencies,attention-deficit/hyperactivity disorder(ADHD),sleep disturbances,autism spectrum disorder,and cognitive impairment.These associations are influenced by multiple factors,including genetic predisposition,individual characteristics,AD se-verity,and adverse lifestyle habits.The underlying mechanisms primarily involve bidirectional in-teractions of the"brain-skin axis"(encompassing neuroendocrine regulation,hypothalamic-pitui-tary-adrenal axis,and sympathetic nervous system),neuroimmune inflammation,and genetic reg-ulation.Medications that effectively control the symptoms of atopic dermatitis(such as biologics)often improve associated psychiatric comorbidities,while interventions targeting mental health symptoms can also alleviate AD symptoms.Therefore,clinicians should fully recognize and screen for psychiatric comorbidities in patients with AD,and adopt an integrated management strategy that combines dermatological treatment with psychological interventions.Future research should aim to further elucidate the underlying mechanisms to optimize therapeutic approaches.This article reviews the epidemiology,influencing factors,pathogenesis,and therapeutic progress related to the psychiatric comorbidities of atopic dermatitis.
Keywords：atopic dermatitispsychiatric comorbiditiesinfluencing factorspathogene-sistherapeutic progress
Publication Date：2025-08-28
Online Publishing Date：2025-09-23(First online date of this platform, not the publication date of the document)
Pages：9( 604-612 )