Advances in the application of Chlamydia trachomatis Pgp3 and its antibodies in serological detection
ZHOU Han
CHEN Wentao
CHEN Yang
ZHANG Ziyan
ZHENG Heping
Abstract：Chlamydia trachomatis infection has become a major global public health concern.Pgp3,a virulence protein encoded by a cryptic plasmid,features a highly conserved trimeric struc-ture and plays a pivotal role in C.trachomatis pathogenesis by neutralizing the antimicrobial pep-tide LL-37 and activating the TNFR1 signaling pathway.As an immunodominant protein,Pgp3-based serological assays(ELISA/MBA/LISA)demonstrate significantly superior performance compared to traditional MOMP detection.Pgp3 antibodies persist for over 12 years,making them ideal markers for assessing past infections.Furthermore,Pgp3 seropositivity is significantly associ-ated with tubal infertility(aOR=2.6)and pelvic inflammatory disease(PR=2.0),highlighting its potential for predicting deep-tissue infections.This review systematically analyzes the structure of the Pgp3 protein,its pathogenic mechanisms,and the application of its antibodies in evaluating past infections and predicting deep infections,thereby providing a theoretical foundation for prog-nostic evaluation of C.trachomatis infections.
Keywords：Chlamydia trachomatisPgp3serological detectionprevious infectiondeep infection
Publication Date：2025-08-28
Online Publishing Date：2025-09-23(First online date of this platform, not the publication date of the document)
Pages：6( 598-603 )